Essay --

Participation of hyperglycemia in triggering the multiple oxidative stress pathways in the course of diabetes. AngII: angiotensin II; eNOS: endothelial nitric oxide synthase; Jac/STAT: janus kinase (Jac)-signal transducer and activator of transcription (STAT); LDL: low density lipoprotein cholesterol; MAPK: mitogen-activated protein kinase; MetS: metabolic syndrome; NF-ÃŽ ºb: nuclear transcription factor ÃŽ ºb; †¢NO: nitric oxide; NOS: nitric oxide synthase; †¢O2−: superoxide anion radical; †¢OH: hydroxyl radical; ONOO−: peroxynitrite; PCKÃŽ ´: protein kinase C ÃŽ ´. Adapted from Johansen et al., 2005 The increased oxidative stress in subjects with type 2 diabetes is therefore a magnitude of several abnormalities, including hyperglycemia, insulin resistance, hyperinsulinemia, and dyslipidemia, each of which contributes to mitochondrial superoxide overproduction in endothelial cells of large and small vessels as well as the myocardium[15] COMPLICATIONS OF DIABETES Whether diabetes occurs as a result of type 1, the early-onset and predominantly insulin-dependent form, or type 2, the late-onset... Essay -- Participation of hyperglycemia in triggering the multiple oxidative stress pathways in the course of diabetes. AngII: angiotensin II; eNOS: endothelial nitric oxide synthase; Jac/STAT: janus kinase (Jac)-signal transducer and activator of transcription (STAT); LDL: low density lipoprotein cholesterol; MAPK: mitogen-activated protein kinase; MetS: metabolic syndrome; NF-ÃŽ ºb: nuclear transcription factor ÃŽ ºb; †¢NO: nitric oxide; NOS: nitric oxide synthase; †¢O2−: superoxide anion radical; †¢OH: hydroxyl radical; ONOO−: peroxynitrite; PCKÃŽ ´: protein kinase C ÃŽ ´. Adapted from Johansen et al., 2005 The increased oxidative stress in subjects with type 2 diabetes is therefore a magnitude of several abnormalities, including hyperglycemia, insulin resistance, hyperinsulinemia, and dyslipidemia, each of which contributes to mitochondrial superoxide overproduction in endothelial cells of large and small vessels as well as the myocardium[15] COMPLICATIONS OF DIABETES Whether diabetes occurs as a result of type 1, the early-onset and predominantly insulin-dependent form, or type 2, the late-onset...